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1.
Front Psychol ; 14: 1192555, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37519359

RESUMO

Introduction: Executive functions are a set of mental abilities that allow human beings to consciously regulate their behavior and, in a university setting, will have a significant impact on student success during professional training. Objective: To develop a scale to assess executive functions in a university setting. Method: Using a sample of 1,373 university students from Chile (663) and Ecuador (710) between 17 and 33 years old (Mage = 20.53, SD = 2.34). A study was carried out to analyze the psychometric properties of the instrument using a reliability and validity analysis for a scale that assesses executive functions: conscious monitoring of responsibilities, supervisory attentional system, conscious regulation of behavior, verification of behavior to learn, decision making, conscious regulation of emotions, and management of elements to solve tasks. Results: Adequate internal consistency parameters were found between α = 0.71 and 0.85. The seven executive functions proposed on the scale correlated proportionally between r = 0.42 and 0.62. In the confirmatory factor analysis, good fit indices were obtained in the model of the seven executive functions x2(413) = 1649.14, p = <0.001, CFI = 0.91, SRMR = 0.04 and RMSEA = 0.04. Discussion: The research carried out reaches its conclusion stating that the scale that was developed has the psychometric properties to assess executive functions in the Latin American setting. The results regarding previous research and the contribution made in the line of research of executive functions are discussed.

2.
Rev. mex. trastor. aliment ; 13(1): 85-107, ene.-jun. 2023. tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1530220

RESUMO

Resumen Se realizó una revisión de literatura con el objetivo de identificar los factores de riesgo de la BN, utiles para que el equipo de salud proteja la seguridad de sus intervenciones y atención a las personas que padecen este trastorno en el ciclo de vida adolescente y joven. Se hizo una búsqueda en bases de datos y repositorios, con uso de términos libres como: BN, adolescente, factor de riesgo, trastorno de conducta alimentaria, en español e inglés, combinados con operadores boleanos (AND, OR, NOT) y de posición (WTH y NEAR). Se incluyeron 72 documentos tras la selección por criterios de inclusión, se hizo depuración de ellos según sus datos bibliográficos, objetivo, tipo de estudio, resultados y conclusión. Los resultados muestran que hay aún factores biológicos por rastrear y analizar, dentro de los sociodemográficos, la edad de afectación principalmente reportada es la adolescencia y adultez joven, no hubo diferencias por raza o nivel socioeconómico. Factores comportamentales como preocupación por la imagen corporal, dietas y ejercicio son documentados. Desde el área psicosocial, la disfuncionalidad individual y los antecedentes de trastornos psicológicos, la familia y el entorno cultural condicionan para que el cuerpo logre su delgadez. La conclusión general sugiere que la seguridad de la atención en la BN está en explorar los antecedentes individuales, biológicos, psicológicos y comportamentales; reconocer dinámicas familiares y la influencia del entorno social. Asimismo, es útil, el trabajo interdisciplinar e integración de red de apoyo familiar para lograr atención segura en la BN.


Abstract Review of literature aimed at recognizing risk factors of BN, useful for the health team to protect the safety of their interventions and care for people suffering from this disorder in the adolescent and young life cycle. It consists of a narrative review, carried out by means of search in databases and repositories, with use of free terms such as: BN, adolescent, risk factor, food behavior disorders, in Spanish and English, combined with bolean operators (AND, OR, NOT) and position (WTH and NEAR). Seventy-two sources were incorporated, documents were selected by inclusion criteria, review according to bibliographic data, objective, type of study, results, and conclusion. The results show that there are still biological factors to be traced and analyzed, within the sociodemographic the age of involvement is adolescence and youth, it does not have differences by race or socioeconomic level. Behavioral factors such as concern for body image, diets and exercise are documented. From the psychosocial area, individual dysfunction and backgrounds of psychological disorders, the family and the cultural environment influence to achieve the thinness of the body. The general conclusion suggests that the safety of care in the BN lies in exploring the individual, biological, psychological and behavioral backgrounds, recognizing family dynamics and the influence of the social environment. It is useful, interdisciplinary work and integration of family support network to achieve safe health care in the BN.

3.
Sci Total Environ ; 877: 162916, 2023 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-36934918

RESUMO

Monitoring wildlife populations to determine changing abundance is the basis for conservation strategies and interventions. Monitoring, however, is expensive, and we lack baseline data for countless species and landscapes around the globe. One solution is to utilize methods that leverage observations collected by everyday people. Humans are not only excellent sensors for diverse data, but possess a remarkable ability to process data and differentiate patterns with minimal training. Here, we explored the potential for people, including guides who work in tourism in southern Patagonia, to determine whether paired photographs of puma (Puma concolor puma) faces were the same individual, akin to a computer-led Siamese network analysis. Overall, participants performed well (average score of 92.2 %) and we detected no differences in local people versus those from the USA, or differences due to differential experience working with pumas. Based on these results, we built a historic capture-recapture dataset of individual pumas collected by local guides and report annual abundance for a portion of the Torres del Paine UNESCO Biosphere in southern Chile, an area lacking such data and of critical conservation for the species. Our results highlight the innate capabilities of human computers and their potential for contributing to wildlife surveys in novel ways to increase science capacity.


Assuntos
Puma , Animais , Humanos , Turismo , Animais Selvagens , Chile
5.
Front Oncol ; 13: 1091329, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36959795

RESUMO

Older cancer patients are disproportionally affected by the Coronavirus 19 (COVID-19) pandemic. A higher rate of death among the elderly and the potential for long-term disability have led to fear of contracting the virus in these patients. This fear can, paradoxically, cause delay in diagnosis and treatment that may lead to a poor outcome that could have been prevented. Thus, physicians should devise a policy that both supports the needs of older patients during cancer treatment, and serves to help them overcome their fear so they seek out to cancer diagnosis and treatment early. A combination of telemedicine and a holistic approach, involving prayers for older cancer patients with a high level of spirituality, may improve vaccination rates as well as quality of life during treatment. Collaboration between health care workers, social workers, faith-based leaders, and cancer survivors may be crucial to achieve this goal. Social media may be an important component, providing a means of sending the positive message to older cancer patients that chronological age is not an impediment to treatment.

6.
Transplant Proc ; 55(2): 466-469, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36849337

RESUMO

BACKGROUND: Pulmonary nodules in asymptomatic patients could represent latent pulmonary infections. Intestinal transplant (ITx) recipients with preexisting lung nodules might be at higher risk for pulmonary infections. However, data is scarce. METHODS: This retrospective study included adult patients who underwent ITx from May 2016 to May 2020. Chest computed tomography scans performed within 12 months before ITx were obtained to evaluate for preexisting pulmonary nodules. Screening for endemic mycoses, Aspergillus, Cryptococcus, and latent tuberculosis infection performed within 12 months before ITx was obtained. We assessed for worsening pulmonary nodules, and fungal and mycobacterial infections during the first year post-transplant. Survival and graft loss at 1-year post-transplant was also assessed. RESULTS: Forty-four patients underwent ITx. Thirty-one had preexisting lung nodules. No invasive fungi were recorded in the pretransplant period and one individual had latent tuberculosis infection. In the post-transplant period, one individual developed probable invasive aspergillosis and had worsening nodular opacities, whereas one had disseminated histoplasmosis with stable lung nodules in chest computed tomography. No mycobacterial infections were documented. The cohort survival was 84% at 12 months after transplant. CONCLUSION: Preexisting pulmonary nodules were common in the cohort (71%), yet latent and active pulmonary infections were rare. Appearance of new or worsening pulmonary nodules does not appear to directly correlate with pulmonary infections in the post-transplant period. Routine chest computed tomography is not recommended in the pretransplant period, but follow-up is favored in patients with confirmed nodular opacities. Clinical monitoring is essential.


Assuntos
Aspergilose , Tuberculose Latente , Pneumonia , Adulto , Humanos , Transplantados , Estudos Retrospectivos , Pulmão/microbiologia
7.
Artigo em Inglês | MEDLINE | ID: mdl-36673883

RESUMO

Falling events are a global health concern with short- and long-term physical and psychological implications, especially for the elderly population. This work aims to monitor human activity in an indoor environment and recognize falling events without requiring users to carry a device or sensor on their bodies. A sensing platform based on the transmission of a continuous wave (CW) radio-frequency (RF) probe signal was developed using general-purpose equipment. The CW probe signal is similar to the pilot subcarriers transmitted by commercial off-the-shelf WiFi devices. As a result, our methodology can easily be integrated into a joint radio sensing and communication scheme. The sensing process is carried out by analyzing the changes in phase, amplitude, and frequency that the probe signal suffers when it is reflected or scattered by static and moving bodies. These features are commonly extracted from the channel state information (CSI) of WiFi signals. However, CSI relies on complex data acquisition and channel estimation processes. Doppler radars have also been used to monitor human activity. While effective, a radar-based fall detection system requires dedicated hardware. In this paper, we follow an alternative method to characterize falling events on the basis of the Doppler signatures imprinted on the CW probe signal by a falling person. A multi-class deep learning framework for classification was conceived to differentiate falling events from other activities that can be performed in indoor environments. Two neural network models were implemented. The first is based on a long-short-term memory network (LSTM) and the second on a convolutional neural network (CNN). A series of experiments comprising 11 subjects were conducted to collect empirical data and test the system's performance. Falls were detected with an accuracy of 92.1% for the LSTM case, while for the CNN, an accuracy rate of 92.1% was obtained. The results demonstrate the viability of human fall detection based on a radio sensing system such as the one described in this paper.


Assuntos
Aprendizado Profundo , Humanos , Idoso , Redes Neurais de Computação , Radar , Atividades Humanas
8.
Behav Sci (Basel) ; 12(11)2022 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-36354397

RESUMO

Social distancing and security measures have contained the spread of the COVID-19 pandemic. Despite this, the return to face-to-face activities is necessary for specific companies, and some higher education institutions have already done so. The various disorders that this new reality could generate have motivated the present study, which aims to analyze the emotional state of teachers and administrative staff. The instrument used was the abbreviated depression, anxiety, and stress scale (DASS-21), with an internal consistency index of 0.87. The methodology was based on applying a survey to 202 participants from Quito, Ecuador. The sample consisted of 97 men and 105 women aged between 23 and 59 years. A quantitative and cross-sectional design was used in this research. The results show that 40.1% of the respondents presented anxiety, 36.63% depression, and 38.61% stress between mild and highly severe categories. Additionally, when analyzing the depression, anxiety, and stress levels compared to productivity variables, we found that five disorders, i.e., fear, anxiety, over reactivity, skeletal muscle effects, and dysphoria, directly affect productivity variables, such as performing simple tasks, performing difficult tasks, the number of products made, and the number of products rejected. Thus, returning to face-to-face mode has affected the emotional state of many people, showing differences according to the job position, with anxiety being the highest self-identified incidence rate.

9.
ACS Appl Mater Interfaces ; 14(40): 45342-45351, 2022 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-36191154

RESUMO

Additive manufacturing can enable the fabrication of batteries in nonconventional form factors, enabling higher practical energy density due to improved material packing efficiency of power sources in devices. Furthermore, energy density can be improved by transitioning from conventional Li-ion battery materials to lithium metal anodes and conversion cathodes. Iron disulfide (FeS2) is a prominent conversion cathode of commercial interest; however, the direct-ink-write (DIW) printing of FeS2 inks for custom-form battery applications has yet to be demonstrated or optimized. In this work, DIW printing of FeS2 inks is used to systematically investigate the impact of ink solid concentration on rheology, film shape retention on arbitrary surfaces, cathode morphology, and electrochemical cell performance. We find that cathodes with a ridged interface, produced from the filamentary extrusion of highly concentrated FeS2 inks (60-70% solids w/w%), exhibit optimal power, uniformity, and stability when cycled at higher rates (in excess of C/10). Meanwhile, cells with custom-form, wave-shaped electrodes (printed FeS2 cathodes and pressed lithium anodes) are demonstrated and shown to exhibit similar performance to comparable cells in planar configurations, demonstrating the feasibility of printing onto complex geometries. Overall, the DIW printing of FeS2 inks is shown to be a viable path toward the making of custom-form conversion lithium batteries. More broadly, ridging is found to optimize rate capability, a finding that may have a broad impact beyond FeS2 and syringe extrusion.

10.
J Emerg Med ; 63(4): 582-591, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36244855

RESUMO

BACKGROUND: Auscultation for an extended period of time using a wearable stethoscope enables objective computerized analysis and longitudinal assessment of lung sounds. However, this auscultation method differs from bedside auscultation in that clinicians are not present to optimize the quality of auscultation. No prior studies have compared these two auscultation methods. OBJECTIVE: The aim of this study was to compare intermittent auscultation using a conventional stethoscope with continuous auscultation using a wearable stethoscope for wheeze detection in patients who present with acute respiratory distress. METHODS: Patients presenting to the emergency department with acute respiratory distress were enrolled. The Strados Remote Electronic Stethoscope Platform (RESP™) was used for continuous auscultation, and intermittent auscultation was performed using a U.S. Food and Drug Administration-cleared electronic stethoscope. A recording was made with an electronic stethoscope. Subsequently, continuous recording was made using RESP™, which continued until the patient was admitted or discharged from the emergency department. The number of captured wheezes in each recording was counted and validated by two board-certified physicians. RESULTS: From May 2018 to May 2019, 43 patients were enrolled in the study. Three patients were excluded from analysis due to incomplete audio recording data. The mean length of recording was 62.3 min for continuous auscultation and 0.7 min for intermittent auscultation; 77.5% (31 of 40) of intermittent recordings contained wheezes, in contrast to 85% (34 of 40) of continuous recordings. CONCLUSIONS: Extending the duration of auscultation using a wearable stethoscope in a noisy clinical environment showed comparable performance to standard of care intermittent auscultation in identifying patients who have wheezes.


Assuntos
Síndrome do Desconforto Respiratório , Estetoscópios , Humanos , Sons Respiratórios/diagnóstico , Auscultação/métodos
11.
Emerg Infect Dis ; 28(9): 1867-1869, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35997627

RESUMO

Ancylostoma ceylanicum hookworms are zoonotic parasites that can infect humans. To detect autochthonous transmission, we analyzed human fecal samples collected in 2000. Multiparallel quantitative PCR detected infection in persons who had never traveled outside Ecuador. These data indicate human transmission of A. ceylanicum in the Americas, although endemicity remains unknown.


Assuntos
Ancilostomíase , Infecções por Uncinaria , Ancylostoma/genética , Ancylostomatoidea , Ancilostomíase/diagnóstico , Ancilostomíase/epidemiologia , Ancilostomíase/parasitologia , Animais , Equador/epidemiologia , Infecções por Uncinaria/epidemiologia , Humanos , Zoonoses
12.
rev. udca actual. divulg. cient ; 25(1): e1850, ene.-jun. 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1395191

RESUMO

ABSTRACT The northern region of the Caldas department in Colombia is considered an endemic area for murine typhus. Recent studies in patients with acute febrile disease demonstrated infection with the spotted fever group's rickettsiae due to an increase in the IgG titer by indirect immunofluorescence in paired sera obtained from these patients. The objective of the current research was to identify the species of ticks present in domestic animals in the northern region of Caldas and establish the presence of rickettsial genomic material in the collected ticks. Ticks were obtained from bovines, horses, and dogs in seven municipalities in the north of Caldas. Ticks were stored in 90 % ethanol until processing and were identified using taxonomic keys, DNA was extracted using commercial techniques, and the gltA gene was amplified by conventional chain reaction polymerase (PCR). Seven hundred thirteen ticks were obtained from 593 domestic animals. The highest infestation occurred in cattle, followed by canines and horses. Ticks found corresponded to the species Riphicephalus microplus, Dermacentor nitens, Amblyomma sp., and Riphicephalus sanguineus s.l. In none of the tick samples, Rickettsia-specific gltA gene DNA was found. It can be inferred that the ticks obtained are not a source of rickettsial infection for people in this department region, despite finding different species associated with the transmission of this disease.


RESUMEN La región norte del departamento de Caldas, Colombia es considerada como una zona endémica de tifo murino. Estudios recientes realizados en pacientes con enfermedad febril aguda, demostraron la infección con rickettsias, del grupo de las fiebres manchadas, debido al aumento en el título de IgG, por inmunofluorescencia indirecta (IFI), en sueros pareados, obtenidos de dichos pacientes. El objetivo de la investigación fue el de identificar las especies de garrapatas presentes en animales domésticos, de la región norte de Caldas y establecer la presencia de material genómico de rickettsias, en las garrapatas recolectadas. En siete municipios, se recolectaron garrapatas de bovinos, de equinos y de caninos. Las garrapatas, se almacenaron en etanol al 90 %, hasta su identificación taxonómica. Se extrajo el ADN, utilizando técnicas comerciales y se amplificó por reacción de cadena de la polimerasa (PCR) convencional el gen gltA. Se obtuvieron 713 garrapatas de 593 animales domésticos. La más alta infestación se presentó en bovinos, seguido de los caninos y equinos. Las garrapatas encontradas correspondieron a las especies Riphicephalus microplus, Dermacentor nitens, Amblyomma sp. y Riphicephalus sanguineus s.l. En ninguna de las muestras, se comprobó la presencia de ADN del gen gltA específico de Rickettsia. Se puede inferir que las garrapatas obtenidas no serían una fuente de infección rickettsial para las personas, en esta región del departamento; sin embargo, su presencia es un factor de riesgo para la adquisición de rickettsiosis asociadas con las fiebres manchadas.

13.
ACS Omega ; 7(16): 13520-13528, 2022 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-35559143

RESUMO

The synthesis of four derivatives and the single-crystal X-ray structures of six 9-trifluoromethylxanthenediols (TFXdiols) I-VI are analyzed in this work. These compounds were obtained through superacid-catalyzed condensation of dihydroxybenzenes with 1,1,1-trifluoroacetone or 2,2,2-trifluoroacetophenone. The title molecules have a convex molecular structure due to their three fused rings of the xanthene moiety. We have found that, similar to resorcinol, the configuration of the hydroxyl groups is of great relevance for the crystal packing favoring either interactions above and below their molecular plane or lateral interactions that create layers. Considering that reports of TFXdiols are very scarce, our findings contribute to a better understanding of the molecular conformation and intermolecular interactions in their crystal structures. A similar analysis was extended to a fortuitous cocrystal obtained between 9-trifluoromethyl-9-(4'-fluorophenyl)-xanthenediol and 1,4-dihydroxybenzene, showing that these structures might be used to obtain cocrystals in the future.

14.
Parasitol Res ; 121(6): 1775-1787, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35435509

RESUMO

Avian haemosporidian from the genera Haemoproteus and Plasmodium are a diverse and widely distributed group of vector-borne blood parasites. These parasites can have negative effects on bird survival by influencing several aspects of their life cycle, causing different clinical signs and even death. Colombia has the widest range of bird richness throughout the globe; however, the associations between haemosporidian parasites and wild birds in different ecosystems remain poorly explored. Within this frame of reference, the objective of the present study was to identify and understand haemosporidian associated with resident and migratory wild birds and their lineages in northeast Orinoquia region, Colombia. Birds were captured in 8 localities and blood samples were collected, identifying the presence of haemosporidian parasites through morphological and molecular analysis of the mitochondrial cytochrome b gene. Blood samples from 233 wild birds (86 species) were analyzed for haemosporidian parasites. Sixteen individuals (6.9%) from 15 resident and migratory species were positive for Haemoproteus or Plasmodium. Fourteen haemosporidian lineages were identified, five of them reported for the first time. These new lineages are reported in four resident birds and one boreal migratory bird (Parkesia noveboracensis). This study is the first developed in the department of Arauca and contributes to the knowledge of haemosporidian lineages and their interaction with wild birds in the Colombian Orinoquia region and South America.


Assuntos
Doenças das Aves , Haemosporida , Parasitos , Plasmodium , Infecções Protozoárias em Animais , Animais , Animais Selvagens , Doenças das Aves/epidemiologia , Doenças das Aves/parasitologia , Aves/parasitologia , Colômbia/epidemiologia , Ecossistema , Haemosporida/genética , Humanos , Filogenia , Plasmodium/genética , Prevalência , Infecções Protozoárias em Animais/epidemiologia , Infecções Protozoárias em Animais/parasitologia
15.
Vet Parasitol Reg Stud Reports ; 30: 100720, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35431076

RESUMO

Wild birds have an important role as hosts of ticks infected by rickettsiae. However, the role of birds as reservoirs of tick-borne rickettsiae is unknown and poorly understood. This is particularly relevant in several tropical and subtropical areas, where migration influences the global spread of ectoparasites and pathogens of public health importance. This research aimed to detect and evaluate the exposure to spotted fever group rickettsiae in wild birds that could represent reservoirs in the Department of Arauca in the Colombian Orinoquia region. Sampling was conducted in three municipalities of the Department of Arauca (Colombia). Blood samples were collected from 255 birds and processed to obtain serum (n = 155) and DNA (n = 255) samples. The serum samples were processed for indirect immunofluorescence assays (IFA) for the detection of antibodies to Rickettsia rickettsii, Rickettsia parkeri, Rickettsia amblyommatis, Rickettsia rhipicephali, and Rickettsia bellii. Additionally, we investigated rickettsiae DNA in blood samples by amplification of the citrate synthase gene (gltA). The IFA results revealed seropositivity in 97 samples from 54 species of resident and migratory birds. No sample was positive for rickettsial DNA. The presence of antibodies in 62.5% of the sera indicates previous exposure of these birds to rickettsiae. The null detection of rickettsiae in the blood of seropositive birds is possibly due to a short period of bacteremia. Experimental studies are required to improve our understanding of the role of wild birds as sources of rickettsial infections in ticks.


Assuntos
Infecções por Rickettsia , Rickettsia , Carrapatos , Animais , Animais Selvagens , Aves , Colômbia/epidemiologia , Rickettsia/genética , Infecções por Rickettsia/epidemiologia , Infecções por Rickettsia/veterinária , Estudos Soroepidemiológicos , Carrapatos/microbiologia
16.
Front Psychol ; 13: 1045567, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36721493

RESUMO

Introduction: The learning process of Mathematics is a challenge in Latin America; therefore, it is of vital importance to conduct actions that improve the performance in this science. Methods: This article is reporting on quasi-experimental research, where, through the use of Brain Gym, the objective is to improve: the definition of rational numbers, problem-solving ability, mathematical order relationships, and equivalent fractions. We worked with 67 students between 12 and 14 years old, organized into an experimental group (n = 35) and a control group (no participation group; n = 32). Results: We made pre and post-test measurements and found that the control group students improved in their problem-solving ability F(1,65) = 8.76, p = 0.04, η 2 = 0.12 and equivalent fractions F(1,65) = 4.54, p = 0.03, η 2 = 0.06. Discussion: In conclusion, the importance of applying innovative processes to improve the teaching and learning of Mathematics can be affirmed. It is important to note that both the control and experimental groups improved their learning, however, the experimental group did so to a greater extent than the students in the control group, who received a traditional educational process, and they did learn, but not at the level of the experimental group.

17.
Technol Forecast Soc Change ; 173: 121179, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34511647

RESUMO

The COVID-19 crisis is among the most disruptive events in recent decades. Its profound consequences have garnered the interest of many studies in various disciplines, including consumer behavior, thereby warranting an effort to review and systematize the literature. Thus, this study systematizes the knowledge generated by 70 COVID-19 and consumer behavior studies in the Scopus database. It employs descriptive analysis, highlighting the importance of using quantitative methods and China and the US as research settings. Co-occurrence analysis further identified various thematic clusters among the studies. The input-process-output consumer behavior model guided the systematic review, covering several psychological characteristics and consumer behaviors. Accordingly, measures adopted by governments, technology, and social media stand out as external factors. However, revised marketing strategies have been oriented toward counteracting various consumer risks. Hence, given that technological and digital formats mark consumer behavior, firms must incorporate digital transformations in their process.

18.
Sensors (Basel) ; 21(15)2021 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-34372358

RESUMO

The growing elderly population living independently demands remote systems for health monitoring. Falls are considered recurring fatal events and therefore have become a global health problem. Fall detection systems based on WiFi radio frequency signals still have limitations due to the difficulty of differentiating the features of a fall from other similar activities. Additionally, the antenna orientation has not been taking into account as an influencing factor of classification performance. Therefore, we present in this paper an analysis of the classification performance in relation to the antenna orientation and the effects related to polarization and radiation pattern. Furthermore, the implementation of a device-free fall detection platform to collect empirical data on falls is shown. The platform measures the Doppler spectrum of a probe signal to extract the Doppler signatures generated by human movement and whose features can be used to identify falling events. The system explores two antenna polarization: horizontal and vertical. The accuracy reached by horizontal polarization is 92% with a false negative rate of 8%. Vertical polarization achieved 50% accuracy and false negatives rate.


Assuntos
Acidentes por Quedas , Monitorização Ambulatorial , Idoso , Algoritmos , Humanos , Movimento , Ondas de Rádio
19.
Cancers (Basel) ; 13(15)2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34359682

RESUMO

Ewing sarcoma is an aggressive bone cancer affecting children and young adults. The main molecular hallmark of Ewing sarcoma are chromosomal translocations that produce chimeric oncogenic transcription factors, the most frequent of which is the aberrant transcription factor EWSR1-FLI1. Because this is the principal oncogenic driver of Ewing sarcoma, its inactivation should be the best therapeutic strategy to block tumor growth. In this study, we genetically inactivated EWSR1-FLI1 using CRISPR-Cas9 technology in order to cause permanent gene inactivation. We found that gene editing at the exon 9 of FLI1 was able to block cell proliferation drastically and induce senescence massively in the well-studied Ewing sarcoma cell line A673. In comparison with an extensively used cellular model of EWSR1-FLI1 knockdown (A673/TR/shEF), genetic inactivation was more effective, particularly in its capability to block cell proliferation. In summary, genetic inactivation of EWSR1-FLI1 in A673 Ewing sarcoma cells blocks cell proliferation and induces a senescence phenotype that could be exploited therapeutically. Although efficient and specific in vivo CRISPR-Cas9 editing still presents many challenges today, our data suggest that complete inactivation of EWSR1-FLI1 at the cell level should be considered a therapeutic approach to develop in the future.

20.
Front Psychol ; 12: 585145, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34135795

RESUMO

The process of assessing executive functions through behavioral observation scales is still under theoretical and empirical construction. This article reports on the analysis of the factorial structure of the EOCL-1 scale that assesses executive functions, as proposed by the theory developed by Luria, which has not been previously considered in this type of evaluation. In this scale, the executive functions taken into account are error correction, internal behavioral and cognition regulatory language, limbic system conscious regulation, decision making, future consideration of consequences of actions, goal-directed behavior, inhibitory control of automatic responses, creation of new behavioral repertoires, and cognitive-behavioral activity verification. A variety of validity and reliability analyses were carried out, with the following results: (a) an adequate internal consistency level of executive functions between α = 0.70 and α = 0.83, (b) significant convergent validity with a scale that assesses frontal deficits between r = -0.07 and r = 0.28, and (c) the scale's construct validity that proposes a model with an executive central factor comparative fit index (CFI) = 0.93, root mean square error of approximation (RMSEA) = 0.04 (LO.04 and HI.04), standardized root mean square residual (SRMR) = 0.04, and x2 ( 312 ) = 789.29, p = 0.001. The findings are discussed based on previous literature reports and in terms of the benefits of using a scale to assess the proposed executive functions.

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